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Integrative Regenerative Medicine

IRM™ EWOT with H+ Poising Bioenergetics[1]

(EWOT -> Exercise With Oxygen Therapy)

© 2016-2017 International College of Regenerative Medicine™

To view a PDF copy and print this protocol, click here.

 

Tue-Thu-Sat-Sun -> OBTAIN A STATIONARY AEROBIC EXERCISE MACHINE (e.g. Gazelle, Rebounder, Rowing Machine, Bicycle trainer, Stair Steps):

Ø  Treatment Session Duration Tuesday, Thursday, Saturday & Sunday.

Ø  Treatment Duration 30 minutes (average intensity) to 4 minutes (high intensity).

Ø  Settings Oxygen concentrator set @ 10LPM. Purchase O2 Bag reserve when available to obtain higher LPM.

 

EWOT ACCESSORIES:

1)    Pair of – DrPeds™ +

2)    1 - MaxO2™ +

3)    1 - DrWand™ 100 on tripod positioned to aim light at heart.

4)    Optional but recommended if in the budget:

a.     1 - DrStim™ 100 – (IRB Registered Clinics Only) Electropads applied to main gait muscles of legs & arms (e.g., gastrocnemius, Rectus femoris, biceps);[2]

b.     BioAcoustics™ Frequencies (upregulation of Krebs’s Cycle and Antiinflammation).

 

FIRST PROTOCOL -> AVERAGE INTENSITY EWOT PROTOCOL: [3],[4]

Exercise at a pace that pushes you but is well tolerated while breathing in O2 over 30 minutes.

 

SECOND PROTOCOL -> ULTIMATE HIGH INTENSITY INTERVAL TRAINING (UHIIT) EWOT PROTOCOL: [5],[6],[7],[8]

Once you are in shape: (1) after 3 or more weeks of practicing the Average Intensity EWOT Protocol, and if (2) your doctor approves (rules out medical conditions which are contra-indicated), proceed as follows:

1.     Perform 8 to 15 minutes of your Qi Gong routine before getting into the EWOT station;

2.     EWOT station - Warm up for 10 minutes at average intensity pace;

3.     At the 10-minute mark, go into a full, all-out sprint for 20 seconds;

4.     Then instantly rest completely for 10 seconds;

5.     Then repeat this cycle 7 more times (8 cycles in all over a span of just 4 minutes);

6.     This is the Tabata Method which research confirms is greatly superior to one to two hours of continuous aerobic exercise;[9]

7.     Afterwards, immediately lay down and rest for 5 minutes, while using Psychoneurosomatics™ over each part of the body that was the most exerted during the high intensity EWOT session;

8.     If not taking silver and/or copper hydrosol, drink your allotted amount of Alkaline Drink according to body weight (induces mitochondrial biogenesis).[10],[11],[12],[13]


What Are The Benefits of Exercising With Oxygen Therapy (EWOT)

And What Added Benefits Happen When You Consume an Alkaline Drink Under Supervision?[A] 

EWOT is indispensable to regenerative medicine. When properly done for 4 to 30 minutes three to four times weekly, fantastic things happen to your body, such as:

  1. A return to producing healthy growth hormone levels to that of a much younger you.[14],[15]
  2. Safely strengthens & rejuvenates your heart, lungs and muscles.[16],[17],[18],[19],[20],[21],[22]
  3. Dramatically improves your circulation.[23],[24],[25]
  4. Easily controls weight and blood sugar issues.[26],[27],[28]
  5. Excellent reliever of stress.[29]
  6. Appears to reduce autoimmune inflammation and inflammation associated with aging.[30],[31]
  7. Emerging evidence suggests EWOT rapidly clears metabolic wastes by preventing hypoxic conditions during exercise.[32],[33]
  8. Only 4 minutes of this system of EWOT has been shown to be superior than 1 to 2 hours of standard aerobic exercises.[34],[35],[36],[37]
  9. Using High Intensity Interval Training (HIIT) for EWOT has additional benefits in terms of you acquiring optimal fitness and dramatically lessening your post-exercise fatigue.[38],[39],[40],[41],[42],[43],[44]
  10.  Causes you to become leaner and less fat, and helps increase your life span.[45],[46]
  11.  Using as prescribed an alkalinizing drink pre- or post- EWOT offers (a) fastest recovery time, (b) enhanced endurance, (c) enhanced performance, (c) optimal muscle building results, and perhaps most importantly è (d) dramatic, sustained increases in your daily energy levels.[47],[48],[49],[50],[51],[52]
  12.  Using potassium bicarbonate may offer the optimal means for: alkalinizing tissues,[53],[54], [55] preventing loss of bone integrity,[56] dissolving kidney stones,[57] and reducing cardiovascular risk factors.[58] It may also greatly reduce undesirable cell proliferation when taken with the sugar ribose.[59]
  13.  Curcumin,[60] Ribose[61], PQQ,[62],[63] CoQ10,[64] Carnitine,[65] R-ALA,[66],[67] and Vitamin B-3[68], all greatly enhance mitochondrial function and/or the optimal replication rate of mitochondria.

[A] 20 - 35 grams daily of bicarbonate in liquid – see Eur J Appl Physiol. 2014;114:1715-24. See also - Sports Med. 2015;45(Suppl 1):S71-S81; and Sports Med. 2011 Oct 1;41(10):801-14. As well as - J Sports Sci. 1992;10:415–23. Ideal daily intake appears to be ~21 grams for up to 12 weeks and then discontinuing. Side reactions have never been seen with this dosage schedule. Rat studies showed side reactions would only arise with dosages ~300% higher and over longer time frames (i.e., side reactions only occurred after 13 weeks of ingestion, and not before then). See: Food Chem Toxicol. 2004 Jan;42(1):135-53.


REFERENCES

[1] Von Ardenne M. Oxygen Multistep Therapy: Physiological and Technical Foundations. Thieme, New York, 1990. ISBN 0-86577-377-7.

[2] Wahl P, et al. Acute metabolic, hormonal and psychological responses to cycling with superimposed electromyostimulation. Eur J Appl Physiol. 2014 Nov;114(11):2331-9.

[3] Zueger T, et al. Exercise-induced GH secretion in the assessment of GH deficiency in adult individuals. Eur J Endocrinol. 2011 Nov;165(5):723-8.

[4] Von Ardenne M. Oxygen Multistep Therapy: Physiological and Technical Foundations. Thieme, New York, 1990. ISBN 0-86577-377-7.

[5] Mangine GT, et al. Exercise-Induced Hormone Elevations Are Related to Muscle Growth. J Strength Cond Res. 2017 Jan;31(1):45-53.

[6] Buchheit M1, Laursen PB. High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Med. 2013 May;43(5):313-38.

[7] Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med. 2013 Oct;43(10):927-54.

[8] Peake JM, et al. Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise. Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E539-52.

[9] The Tabata Method performed just 4 times weekly for 6 weeks increased anaerobic capacity by 28% compared to 0% improvement from one hour aerobic stationary bicycling 5 times per week for 6 weeks. Additionally, the Tabata Method performed just 4 times weekly improved maximal aerobic power by 15% compared to only 10% improvement from one hour aerobic stationary bicycling 5 times per week for 6 weeksSee: http://fitness.mercola.com/sites/fitness/archive/2013/06/21/interval-training.aspx#_edn6

And see: http://www.bodybuilding.com/fun/the-real-tabata-brutal-circuit-from-the-protocols-inventor.html

[10] Percival ME, et al. Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle. J Appl Physiol (1985). 2015 Dec 1;119(11):1303-12.

[11] Hobson RM, et al. Effect of beta-alanine, with and without sodium bicarbonate, on 2000-m rowing performance. Int J Sport Nutr Exerc Metab. 2013 Oct;23(5):480-7.

[12] Wahl P, et al. Effect of high- and low-intensity exercise and metabolic acidosis on levels of GH, IGF-I, IGFBP-3 and cortisol. Growth Horm IGF Res. 2010 Oct;20(5):380-5.

[13] Wahl P, et al. Effects of acid-base balance and high or low intensity exercise on VEGF and bFGF. Eur J Appl Physiol. 2011 Jul;111(7):1405-13.

[14] Wahl P, et al. Effect of high- and low-intensity exercise and metabolic acidosis on levels of GH, IGF-I, IGFBP-3 and cortisol. Growth Horm IGF Res. 2010 Oct;20(5):380-5.

[15] Zueger T, et al. Exercise-induced GH secretion in the assessment of GH deficiency in adult individuals. Eur J Endocrinol. 2011 Nov;165(5):723-8.

[16] Lavie CJ1, Milani RV, Artham SM, Patel DA, Ventura HO. The obesity paradox, weight loss, and coronary disease. Am J Med. 2009 Dec;122(12):1106-14.

[17] Sallam N1, Laher I2. Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases. Oxid Med Cell Longev. 2016;2016:7239639.

[18] Mangine GT, et al. Exercise-Induced Hormone Elevations Are Related to Muscle Growth. J Strength Cond Res. 2017 Jan;31(1):45-53.

[19] Buchheit M1, Laursen PB. High-intensity interval training, solutions to the programming puzzle: Part I: cardiopulmonary emphasis. Sports Med. 2013 May;43(5):313-38.

[20] Buchheit M, Laursen PB. High-intensity interval training, solutions to the programming puzzle. Part II: anaerobic energy, neuromuscular load and practical applications. Sports Med. 2013 Oct;43(10):927-54.

[21] Peake JM, et al. Metabolic and hormonal responses to isoenergetic high-intensity interval exercise and continuous moderate-intensity exercise. Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E539-52.

[22] Carl DL, et al. Preliminary safety analysis of high-intensity interval training (HIIT) in persons with chronic stroke. Appl Physiol Nutr Metab. 2017 Mar;42(3):311-318.

[23] Von Ardenne M. Oxygen Multistep Therapy: Physiological and Technical Foundations. Thieme, New York, 1990. ISBN 0-86577-377-7.

[24] Wahl P, et al. Effects of acid-base balance and high or low intensity exercise on VEGF and bFGF. Eur J Appl Physiol. 2011 Jul;111(7):1405-13.

[25] Jaureguizar KV1, et al. Effect of High-Intensity Interval Versus Continuous Exercise Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease: A RANDOMIZED CLINICAL TRIAL. J Cardiopulm Rehabil Prev. 2016 Mar-Apr;36(2):96-105.

[26] Heydari M, Freund J, Boutcher SH. The Effect of High-Intensity Intermittent Exercise on Body Composition of Overweight Young Males. 2012;(2012):Article ID 480467, 8 pages.

[27] Stephenson EJ, Smiles W, Hawley JA. The relationship between exercise, nutrition and type 2 diabetes. Med Sport Sci. 2014;60:1-10.

[28] Galbo H, Tobin L, van Loon LJ. Responses to acute exercise in type 2 diabetes, with an emphasis on metabolism and interaction with oral hypoglycemic agents and food intake. Appl Physiol Nutr Metab. 2007 Jun;32(3):567-75.

[29] Wahl P, et al. Acute metabolic, hormonal and psychological responses to cycling with superimposed electromyostimulation. Eur J Appl Physiol. 2014 Nov;114(11):2331-9.

[30] Deckx N, et al. 12 Weeks of Combined Endurance and Resistance Training Reduces Innate Markers of Inflammation in a Randomized Controlled Clinical Trial in Patients with Multiple Sclerosis. Mediators Inflamm. 2016;2016:6789276.

[31] Haaland DA, et al. Is regular exercise a friend or foe of the aging immune system? A systematic review. Clin J Sport Med. 2008 Nov;18(6):539-48.

[32] Pizzorno J. Is the Diabetes Epidemic Primarily Due to Toxins? Integr Med (Encinitas). 2016 Aug;15(4):8-17.

[33] Machado P, et al. Moderate exercise increases endotoxin concentration in hypoxia but not in normoxia: A controlled clinical trial. Medicine (Baltimore). 2017 Jan;96(4):e5504.

[34] The Tabata Method performed just 4 times weekly for 6 weeks increased anaerobic capacity by 28% compared to 0% improvement from one hour aerobic stationary bicycling 5 times per week for 6 weeks. Additionally, the Tabata Method performed just 4 times weekly improved maximal aerobic power by 15% compared to only 10% improvement from one hour aerobic stationary bicycling 5 times per week for 6 weeks 

See: http://fitness.mercola.com/sites/fitness/archive/2013/06/21/interval-training.aspx#_edn6

And see: http://www.bodybuilding.com/fun/the-real-tabata-brutal-circuit-from-the-protocols-inventor.html

[35] Koichiro A1, Hideo M. Potential Universal Application of High-intensity Interval Training from Athletes and Sports Lovers to Patients. Keio J Med. 2016 Aug 8.

[36] Gayda M, et al. Comparison of Different Forms of Exercise Training in Patients With Cardiac Disease: Where Does High-Intensity Interval Training Fit? Can J Cardiol. 2016 Apr;32(4):485-94.

[37] Jaureguizar KV1, et al. Effect of High-Intensity Interval Versus Continuous Exercise Training on Functional Capacity and Quality of Life in Patients With Coronary Artery Disease: A RANDOMIZED CLINICAL TRIAL. J Cardiopulm Rehabil Prev. 2016 Mar-Apr;36(2):96-105.

[38] Manselin T, Sodergard O. Six Weeks of High Intensity Interval Training with Hyperoxia or Normoxia in Trained Cyclists: A Polarized and Periodized Training Approach. Swedish School of Sport and Health Sciences. 2015:1-30 plus Appendices 1-8.

[39] Chia-Lun H, et al. Effects of Hyperoxia Recovery on Glucose Metabolism and Heart rate variability after High Intensity Interval Training: 2990: Board #93 June 5 9:30 AM - 11:00 AM. Med Sci Sports & Exercise. 2010 May;42(5):820.

[40] Wen-Chih L, et al. Effect of Hyperoxia Recovery After Different Intensity Training on Glucose Tolerance: 1459: Board #61 May 27 11:00AM – 12:30AM. Medicine & Science in Sports & Exercise 2009 May;41(5):20.

[41] Perry CG, Reid J, Perry W, Wilson BA. Effects of Hyperoxic Training on Performance and Cardiorespiratory Response to Exercise. Medicine & Science in Sports Exercise. 2005;37(7):1175-9.

[42] O'Donnell DE, D'Arsigny C, Webb KA. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Amer J Respir Crit Care Med. 2001;163(4):892–8.

[43] Hämäläinen IT, Nummela AT, Ruusko HK. Training in hyperoxia improves 3000-m running performance in national level athletes. Jyväskylä, Finland, KIHU-Research Institute for Olympic Sports. 2000:47.

[44] Astorino T, Robergs RA. Effect of Hyperoxia on Maximal Oxygen Uptake, Blood Acid-Base Balance, and Limitations to Exercise Tolerance. J Exer Physiol. 2003 May;6(2):8-20.

[45] Heydari M, Freund J, Boutcher SH. The Effect of High-Intensity Intermittent Exercise on Body Composition of Overweight Young Males. 2012;(2012):Article ID 480467, 8 pages.

[46] Brida M, et al. Body mass index in adult congenital heart disease. Heart. 2017 Feb 25. pii: heartjnl-2016-310571.

[47] Percival ME, et al. Sodium bicarbonate ingestion augments the increase in PGC-1α mRNA expression during recovery from intense interval exercise in human skeletal muscle. J Appl Physiol (1985). 2015 Dec 1;119(11):1303-12.

[48] Lancha Junior AH, Painelli Vde S, Saunders B, Artioli GG. Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise. Sports Med. 2015 Nov;45 Suppl 1:S71-81.

[49] Krustrup P1, Ermidis G2, Mohr M3. Sodium bicarbonate intake improves high-intensity intermittent exercise performance in trained young men. See comment in PubMed Commons belowJ Int Soc Sports Nutr. 2015 Jun 4;12:25.

[50] Danaher J, Gerber T, Wellard RM, Stathis CG. The effect of β-alanine and NaHCO3 co-ingestion on buffering capacity and exercise performance with high-intensity exercise in healthy males. Eur J Appl Physiol. 2014 Aug;114(8):1715-24.

[51] Hobson RM, et al. Effect of beta-alanine, with and without sodium bicarbonate, on 2000-m rowing performance. Int J Sport Nutr Exerc Metab. 2013 Oct;23(5):480-7.

[52] Wahl P, et al. Effects of acid-base balance and high or low intensity exercise on VEGF and bFGF. Eur J Appl Physiol. 2011 Jul;111(7):1405-13.

[53] Lindinger MI, et al. Role of skeletal muscle in plasma ion and acid-base regulation after NaHCO3 and KHCO3 loading in humans. Am J Physiol. 1999 Jan;276(1 Pt 2):R32-43.

[54] Kryshtal' MV1, Kukoba TV. [Renal mechanisms of protective potassium effect in essential hypertension]. Fiziol Zh. 2003;49(6):38-42.

[55] Frassetto L1, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr. 2001 Oct;40(5):200-13.

[56] Dawson-Hughes B, et al. Potassium Bicarbonate Supplementation Lowers Bone Turnover and Calcium Excretion in Older Men and Women: A Randomized Dose-Finding Trial. J Bone Miner Res. 2015 Nov;30(11):2103-11.

[57] Trinchieri A, Esposito N, Castelnuovo C. Dissolution of radiolucent renal stones by oral alkalinization with potassium citrate/potassium bicarbonate. Arch Ital Urol Androl. 2009 Sep;81(3):188-91.

[58] He FJ, et al. Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives. Hypertension. 2010 Mar;55(3):681-8.

[59] Bruni L, Babarinde AA, Ortalli I, Croci S. K-D:rib dampens Hs 578T cancer cell chemoinvasion and proliferation. Cancer Cell Int. 2014 Aug 12;14:77.

[60] Hamidie R, et al. Curcumin treatment enhances the effect of exercise on mitochondrial biogenesis in skeletal muscle by increasing cAMP levels. Metabolism. 2015 Oct;64(10):1334-47.

[61] Ghanta S, Grossman RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6): 561–574.

[62] Chowanadisai W, et al. Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem. 2010 Jan 1;285(1):142-52.

[63] Harris CB, et al. Dietary pyrroloquinoline quinone (PQQ) alters indicators of inflammation and mitochondrial-related metabolism in human subjects. J Nutr Biochem. 2013 Dec;24(12):2076-84.

[64] Fišar Z, Hroudová J, Singh N, Kopřivová A, Macečková D. Effect of Simvastatin, Coenzyme Q10, Resveratrol, Acetylcysteine and Acetylcarnitine on Mitochondrial Respiration. Folia Biol (Praha). 2016;62(2):53-66.

[65] Nałęcz KA, Nałęcz MJ. [Carnitine - mitochondria and beyond]. Postepy Biochem. 2016;62(2):85-93.

[66] Rochette L, Ghibu S, Muresan A, Vergely C. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Can J Physiol Pharmacol. 2015 Dec;93(12):1021-7.

[67] Lei L, et al. Alpha-lipoic acid attenuates endoplasmic reticulum stress-induced insulin resistance by improving mitochondrial function in HepG2 cells. Cell Signal. 2016 Oct;28(10):1441-50.

[68] Ghanta S, Grossman RE, Brenner C. Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol. 2013 Nov-Dec; 48(6): 561–574.


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